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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tymlos (Abaloparatide) is a synthetic peptide analog of human parathyroid hormone-related protein (PTHrP), used in the treatment of postmenopausal women with osteoporosis who are at high risk for fracture. It works by increasing bone mineral density and bone strength, thereby reducing the risk of spinal and other fractures. Tymlos is administered through a subcutaneous injection and is a part of a comprehensive treatment plan that may include diet changes, exercise, and calcium or vitamin D supplements.
Before you buy Tymlos, it is crucial that you talk to your healthcare provider about potential side effects and Tymlos cost.
| Fact Table | |
|---|---|
| Formula | C174H299N56O49 |
| License | US DailyMed |
| Bioavailability | 36% |
| Legal status | Prescription drug |
| Chemical Name | Abaloparatide |
| Elimination half-life | about 1 h |
| Dosage (Strength) | 80mcg/40mcL (prefilled pen delivers 30 daily doses of 80mcg) |
| Pregnancy | Consult a doctor |
| Brands | Tymlos |
| Protein binding | 70% |
| PubChem CID | 76943386 |
| MedlinePlus | a617038 |
| ChEBI | Not Assigned |
| ATC code | H05AA04 |
| DrugBank | DB05084 |
| KEGG | D10885 |
| Routes of administration | Subcutaneous injection |
Tymlos is administered via subcutaneous injection. Before using, inspect the solution for particulate matter and discoloration. The recommended dose is 80 mcg injected subcutaneously once daily into the abdomen, thigh, or upper arm region. Rotate injection sites to minimize the risk of lipodystrophy and localized cutaneous amyloidosis.
The duration of Tymlos therapy should be determined by your healthcare provider, but treatment typically does not exceed 2 years due to the risk of osteosarcoma observed in animal studies.
Active Ingredient: Abaloparatide (80 mcg per injection).
Due to findings in rat studies, Tymlos may increase the risk of osteosarcoma. It is not recommended for patients with Paget's disease of bone, unexplained elevations of alkaline phosphatase, or prior radiation therapy involving the skeleton.
Tymlos may cause orthostatic hypotension. Patients should sit or lie down if they feel dizzy or lightheaded until the symptoms resolve.
Monitor serum calcium levels as Tymlos medication can cause hypercalcemia.
Patients with active urolithiasis should not use Tymlos.
Tymlos is not recommended for use during pregnancy or breastfeeding due to the lack of sufficient data on its safety in these populations.
Using Tymlos with other medications for osteoporosis has not been evaluated for safety and efficacy and is generally not recommended. High doses of calcium or vitamin D supplements may contribute to the risk of hypercalcemia when taken with Tymlos. Medications that alter electrolyte balance may increase the risk of adverse effects with Tymlos.
Common side effects include:
Serious side effects include:
What is Tymlos used for?
Tymlos is used to treat osteoporosis in postmenopausal women who are at high risk for fracture.
How is Tymlos administered?
Tymlos is administered through a subcutaneous injection once daily.
Can Tymlos cure osteoporosis?
Tymlos cannot cure osteoporosis but can significantly reduce the risk of fractures by increasing bone density and strength.
What are the common side effects of Tymlos?
Common side effects include nausea, dizziness, headache, palpitations, and injection site reactions.
Is Tymlos safe for long-term use?
The safety of Tymlos use beyond 2 years has not been established due to the potential risk of osteosarcoma.
Can Tymlos be used with other osteoporosis medications?
The safety and efficacy of using Tymlos with other osteoporosis medications have not been established. Talk to your healthcare provider for more information.
What should I do if I miss a dose of Tymlos?
If you miss a dose, administer it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule.
How should I store Tymlos?
Store Tymlos in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the pen cap on when not in use to protect from light.
Can Tymlos cause hypercalcemia?
Yes, Tymlos can cause hypercalcemia. Monitor your calcium levels as directed by your healthcare provider.
Who should not use Tymlos?
Individuals with a history of hypersensitivity to abaloparatide or any of the product's components, those with high risk factors for osteosarcoma, pregnant or breastfeeding women, and patients with active urolithiasis should not use Tymlos.
