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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tremfya (guselkumab) is an innovative prescription medication used primarily for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. Guselkumab, the active ingredient in Tremfya, is a biologic medication that specifically targets the interleukin-23 (IL-23) protein, a key player in the inflammatory process of psoriasis. This targeted action helps to reduce the signs and symptoms of the condition, leading to clearer skin and better control over psoriatic inflammation.
Before you buy Tremfya, it is crucial that you talk to your healthcare provider about potential side effects and Tremfya cost.
| Fact Table | |
|---|---|
| Active Ingredient | Guselkumab |
| License | FDA approved |
| Bioavailability | Not fully established (biological agent) |
| Legal status | Prescription drug |
| Chemical Name | Guselkumab |
| Elimination half-life | Approx. 15-19 days |
| Dosage (Strength) | 100 mg/mL |
| Pregnancy | Use only if clearly needed |
| Brands | Tremfya |
| Protein binding | High (like other monoclonal antibodies) |
| DrugBank | DB13924 (Guselkumab) |
| ATC code | L04AC16 |
| KEGG | D11030 (Guselkumab) |
| Routes of administration | Subcutaneous injection |
Tremfya is available only with a doctor's prescription. Follow your healthcare provider's instructions precisely.
Tremfya is administered as a subcutaneous injection. The recommended dose is 100 mg at Weeks 0 and 4, followed by a maintenance dose of 100 mg every 8 weeks thereafter.
Injections should be given under the skin, in the thigh, abdomen, or upper arm regions. Rotate the injection sites with each dose to reduce discomfort and skin reactions.
Active Ingredient: Guselkumab
Guselkumab may increase the risk of infections. Before starting treatment, patients should be tested for tuberculosis infection.
Severe allergic reactions have been reported with Tremfya. Discontinue use if serious hypersensitivity reactions occur.
Live vaccines should not be given concurrently with Tremfya. Discuss all vaccinations with your healthcare provider before starting treatment.
Regular monitoring of signs of infection is recommended during treatment.
Periodic skin examinations are advised for all patients, particularly those with a history of skin cancer.
Drug interactions include immunosuppressants and live vaccines. Patients should inform their healthcare providers of all medications they are taking, including over-the-counter drugs, vitamins, and herbal supplements.
Common side effects of Tremfya injection include:
What does Tremfya treat?
Tremfya, also known as guselkumab, is used to treat moderate to severe plaque psoriasis and psoriatic arthritis in adults.
How does Tremfya work?
Tremfya works by blocking a protein called interleukin-23 (IL-23) in your body, which normally activates your immune system. By blocking IL-23, Tremfya lowers inflammation in your body to treat symptoms of plaque psoriasis and psoriatic arthritis.
How to inject Tremfya?
Tremfya is injected under the skin. The first two injections are usually given 4 weeks apart, followed by one injection every 8 weeks. You may be shown how to use injections at home.
Is Tremfya an immunosuppressant?
Yes, Tremfya is an immunosuppressant. It works by lowering the activity of your immune system.
Why is Tremfya so expensive?
The cost of Tremfya can vary based on many factors, including whether you have insurance coverage. Other factors may also affect the cost of Tremfya.
How often do you take Tremfya?
Tremfya is administered as a 100 mg subcutaneous injection once every 8 weeks, after starter doses at weeks 0 and 4.
Does Tremfya cause weight gain?
No, Tremfya doesn’t cause weight gain. This side effect wasn’t reported in studies of Tremfya.
How long can Tremfya be out of the fridge?
Tremfya can be left out of the refrigerator for NOT more than 4 hours, ONE-TIME ONLY, before being used.
How long do Tremfya side effects last?
Tremfya side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer, bother you, or become severe, you should talk with your doctor or pharmacist.
How long does Tremfya take to work?
It takes about 16 weeks for Tremfya to start working in most people, which is two doses of Tremfya because each dose is given 8 weeks apart.
