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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Tepmetko (Tepotinib) is a prescription medication used to treat non-small cell lung cancer (NSCLC) that is caused by abnormal mesenchymal-epithelial transition (MET) gene alterations, including MET exon 14 skipping mutations. Tepotinib is a tyrosine kinase inhibitor (TKI) that targets and blocks the activity of the MET protein, helping to slow down or stop the growth of cancer cells. It is typically prescribed for patients whose cancer has spread to other parts of the body (metastatic) and who require targeted therapy. If you're looking to buy Tepmetko, consult your healthcare provider to see if it's right for you.
| Fact Table | |
|---|---|
| Formula | C29H28FN7O |
| License | FDA approved |
| Bioavailability | 71% |
| Legal status | Prescription only |
| Chemical Name | 3-{1-[(S)-2,3-Dihydroxypropyl]-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl}-N-{4-fluoro-2-[(1-methylpiperidin-4-yl)oxy]phenyl}pyridine-2-carboxamide |
| Elimination half-life | 32.4 hours |
| Dosage (Strength) | 225 mg |
| Pregnancy | Contraindicated |
| Brands | Tepmetko |
| Protein binding | 98% |
| PubChem CID | 71261842 |
| MedlinePlus | a621012 |
| ChEBI | 144064 |
| ATC code | L01EX19 |
| DrugBank | DB15347 |
| KEGG | D11531 |
| Routes of administration | By mouth |
Take Tepmetko exactly as prescribed by your healthcare provider. The usual dose is 450 mg (two 225 mg tablets) taken orally once daily. It can be taken with or without food. Swallow the tablets whole with a glass of water; do not crush, chew, or split the tablets. If you miss a dose, take it as soon as you remember unless it is near the time for your next dose. Do not take two doses at the same time to make up for a missed dose.
Each Tepmetko tablet contains the active ingredient Tepotinib hydrochloride hydrate, equivalent to 225 mg of Tepotinib. Inactive ingredients include microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, colloidal silicon dioxide, and magnesium stearate.
Before starting Tepmetko, inform your doctor if you have a history of liver problems, lung disease, or any other significant medical conditions. Tepmetko may cause liver problems, so regular monitoring of liver function is recommended. Avoid using Tepmetko if you are pregnant or planning to become pregnant, as it may harm an unborn baby. It is also advised not to breastfeed while taking this medication and for one week after the last dose.
Tepmetko may interact with other medications, including strong CYP3A inhibitors (e.g., ketoconazole) or inducers (e.g., rifampin), which can affect how Tepotinib works. Avoid grapefruit and grapefruit juice, as they can increase the levels of Tepmetko in your blood, potentially leading to an increased risk of side effects. Inform your healthcare provider of all medications, supplements, and herbal products you are taking to avoid potential interactions.
Common side effects of Tepmetko include swelling (edema) in the hands or feet, nausea, diarrhea, and fatigue. Serious side effects may include liver problems, lung disease (interstitial lung disease or pneumonitis), and severe allergic reactions. Contact your healthcare provider immediately if you experience symptoms such as yellowing of the skin or eyes (jaundice), severe abdominal pain, difficulty breathing, or rash.
What is Tepmetko, and what is it used for?
Tepmetko (tepotinib) is a prescription medication used to treat non-small cell lung cancer (NSCLC) that has a specific type of abnormal gene called MET exon 14 skipping. It is typically prescribed for patients whose cancer has spread (metastatic) or cannot be removed surgically.
How does Tepmetko work?
Tepmetko works by targeting and inhibiting the MET protein, which is involved in the growth and spread of cancer cells. By blocking this protein, Tepmetko helps to slow or stop the growth of cancer cells in patients with NSCLC that has the MET exon 14 skipping mutation.
How is Tepmetko administered?
Tepmetko is an oral medication that comes in tablet form. The usual dose is 450 mg, taken once daily with food. It's important to take the medication exactly as prescribed by your healthcare provider.
What should I do if I miss a dose of Tepmetko?
If you miss a dose of Tepmetko and it is within 8 hours of your usual dosing time, take the missed dose as soon as you remember. If more than 8 hours have passed, skip the missed dose and take your next dose at the regular time. Do not take two doses at once to make up for a missed dose.
What are the common side effects of Tepmetko?
Common side effects of Tepmetko include swelling (edema), nausea, diarrhea, low blood albumin levels, fatigue, decreased appetite, and changes in liver function tests. It's important to report any side effects to your healthcare provider, especially if they are severe or persistent.
Can Tepmetko be taken with other medications?
Tepmetko may interact with other medications, so it's important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and herbal supplements. Your doctor may need to adjust your treatment or monitor you more closely.
Is Tepmetko safe to use during pregnancy or breastfeeding?
Tepmetko is not recommended for use during pregnancy as it may harm an unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least one week after the last dose. It is also not recommended to breastfeed during treatment with Tepmetko and for at least one week after the final dose.
How long will I need to take Tepmetko?
The duration of treatment with Tepmetko varies depending on how well the medication is working and how well you tolerate it. Your healthcare provider will regularly monitor your condition and adjust your treatment plan as necessary.
What should I avoid while taking Tepmetko?
While taking Tepmetko, you should avoid consuming grapefruit or grapefruit juice as it can increase the levels of Tepmetko in your blood, leading to an increased risk of side effects. Additionally, avoid any activities that could result in injury, as Tepmetko can increase the risk of bleeding or bruising.
What should I do if I experience severe side effects or an allergic reaction to Tepmetko?
If you experience severe side effects or signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing, seek immediate medical attention. Contact your healthcare provider right away to report any severe side effects.
