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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
TASIGNA capsules is used to treat a type of leukemia called Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) in adult patients who: are no longer benefitting from another treatment, including treatment with imatinib; have taken other treatments and cannot tolerate them
Fact Table | |
---|---|
Formula | C28H22F3N7O |
License | US DailyMed, EU EMA |
Bioavailability | 30% |
Legal status | Rx-Only |
Chemical Name | Nilotinib |
Elimination half-life | 15-17 hours |
Dosage (Strength) | 75mg, 200mg |
Pregnancy | Not safe |
Brands | Tasigna |
Protein binding | 98% |
PubChem CID | 644241 |
MedlinePlus | a608002 |
ChEBI | 52172 |
ATC code | L01EA03 |
DrugBank | DB04868 |
KEGG | D08953 |
Routes of administration | By mouth |
Take TASIGNA:
-At least 2 hours after eating any food, and
-After taking TASIGNA, wait at least 1 hour before eating any food
-Swallow the capsules whole with water.
-Do NOT open the capsules.
-Avoid grapefruit, grapefruit juice, and any supplement containing grapefruit extract while taking TASIGNA. Food and grapefruit products increase blood levels of TASIGNA in your body.
-If a dose is missed, take the next dose as scheduled. Do not take a double dose to make up for the forgotten capsules.