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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Signifor Lar (Pasireotide) is a long-acting release formulation designed for deep intramuscular injection. As a synthetic derivative of somatostatin, it exhibits a high affinity for somatostatin receptors, thereby exerting a potent inhibitory effect on the excess secretion of growth hormone (GH) and adrenocorticotropic hormone (ACTH), central to the pathophysiology of acromegaly and Cushing's disease, respectively. Available in vial form, each vial of Signifor Lar is intended for single use and is formulated to provide a sustained release of Pasireotide, ensuring consistent therapeutic levels over an extended period.
Before you buy Signifor Lar, it is crucial that you talk to your healthcare provider about potential side effects and Signifor Lar cost.
| Fact Table | |
|---|---|
| Formula | C58H66N10O9 |
| License | FDA approved |
| Bioavailability | 100% (intramuscular) |
| Legal status | Prescription Drug |
| Chemical Name | Pasireotide |
| Elimination half-life | 21.1 days |
| Dosage (Strength) | 10 mg, 20 mg, 30 mg, 40 mg, 60 mg |
| Pregnancy | Consult Doctor |
| Brands | Signifor LAR |
| Protein binding | 88% |
| PubChem CID | 25036595 |
| MedlinePlus | a612014 |
| ChEBI | 78543 |
| ATC code | H01CB05 |
| DrugBank | DB06663 |
| KEGG | D09950 |
| Routes of administration | Intramuscular |
Signifor Lar should be administered once every 4 weeks, strictly via intramuscular injection by a healthcare professional. The dosage varies depending on the patient's condition, response to treatment, and tolerance to the medication. It is crucial to adhere to your healthcare provider's instructions regarding the dosage and schedule to optimize treatment outcomes while minimizing potential risks.
Ensure that the vial is at room temperature. The medication should be reconstituted under sterile conditions using the provided diluent. After reconstitution, the suspension should be inspected for particulate matter and discoloration before administration.
Dosage adjustments may be necessary based on efficacy, tolerability, and the occurrence of side effects. Regular monitoring of hormone levels and clinical symptoms is essential to tailor the treatment to individual needs.
The duration of treatment with Signifor Lar injection is determined by the therapeutic response and tolerability. Long-term therapy may be required in some cases.
The primary active ingredient in Signifor Lar is Pasireotide.
Patients considering Signifor Lar should discuss their complete medical history with their healthcare provider, especially any history of heart conditions, liver disease, gallbladder disease, diabetes, or thyroid disorders. Regular monitoring of blood glucose levels, liver function, and heart health is recommended during treatment.
Signifor Lar should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if Pasireotide is excreted in human milk; caution is advised when administering to breastfeeding mothers.
Patients with known hypersensitivity to Pasireotide or any of the excipients should not use Signifor Lar.
Signifor Lar can interact with various medications, potentially affecting their efficacy or increasing the risk of adverse effects. It is crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking. Special caution is advised when using Signifor Lar with Cytochrome P450 3A4 Substrates, Heart Rhythm Medications and Insulin and Oral Hypoglycemic Agents.
While Signifor Lar is effective in treating certain endocrine disorders, it can cause side effects, ranging from mild to severe. Common side effects include gastrointestinal disturbances (nausea, diarrhea, abdominal pain), hyperglycemia, gallstones, and injection site reactions. More serious but less common side effects include QT prolongation, elevated liver enzymes, and adrenal insufficiency. Patients should seek immediate medical attention if they experience symptoms of severe side effects, such as persistent vomiting, jaundice, or severe abdominal pain.
What is Signifor Lar (Pasireotide)?
Signifor Lar (Pasireotide) is a medication used to treat Cushing’s disease and acromegaly in adults for whom surgery has not worked well enough or who cannot have surgery.
How does Signifor Lar work?
Signifor Lar works by binding to somatostatin receptors on pituitary adenoma cells, inhibiting ACTH secretion and leading to decreased cortisol levels.
What causes Cushing’s disease?
Cushing’s disease occurs when a benign pituitary adenoma secretes excess levels of adrenocorticotropic hormone (ACTH), causing the adrenal glands to secrete cortisol, resulting in excessive circulating cortisol levels.
What causes acromegaly?
Acromegaly is a hormonal disorder that generally develops when your pituitary gland produces too much growth hormone (GH), which then causes your liver to overproduce the hormone insulin-like growth factor 1 (IGF-1).
What are the signs and symptoms of Cushing’s disease?
Signs and symptoms of Cushing’s disease include sudden weight gain, hypertension, facial rounding, easy bruising, striae, glucose intolerance or diabetes mellitus, hyperlipidemia, decreased libido or impotence, menstrual disorders, osteopenia or osteoporosis, acne, hirsutism, recurrent opportunistic bacterial infections, and depression or psychosis.
What are the signs and symptoms of acromegaly?
Some of the most common signs and symptoms of acromegaly include physical changes, such as enlarged hands and feet, changes in facial features, snoring, and weakness/lack of energy.
How is acromegaly diagnosed?
Doctors will perform a biochemical screening as the first step toward diagnosing acromegaly.
How is acromegaly treated?
Doctors often recommend surgery as the initial treatment for the majority of patients. If surgery is not possible or has not improved your condition, your doctor may recommend drug treatment.
What are the side effects of Signifor Lar?
Signifor Lar can cause serious side effects such as high blood sugar (hyperglycemia), diabetes, and ketoacidosis. It can also cause your heart to beat slower, which can cause you to feel weak, dizzy, or even faint.
How is Signifor Lar administered?
Signifor Lar is an injection given by your doctor.
