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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Probenecid is a gout and gouty arthritis treatment medication available by prescription and formulated to prevent uric acid levels from increasing to the point where crystals form in the joints causing these two conditions. It belongs to the uricosuric class of drugs, and it works by supporting the kidneys, so they are more able to eliminate uric acid. Lower uric acid levels are also beneficial for general kidney health. In other use cases Probenecid uses may also involve being prescribed along with an antibiotic because it can promote higher levels of the antibiotic in the blood. Buy Probenecid from Canada and Canpharm and get the best price on it.
Gout is a condition caused by diet, sedentary lifestyle, and other personal factors where are person has excessive purine buildup and this leads to boosted uric acid production. Uric acid then crystallizes in the joints of the toes and fingers causing pain, stiffness, and immobility but it can also occur in other joints. Treatment with medication and diet changes plus maintaining a healthier body weight are usually the keys to overcoming gout.
| Fact Table | |
|---|---|
| Formula | C13H19NO4S |
| License | US DailyMed |
| Bioavailability | greater than 90% |
| Legal status | Prescription Drugs |
| Chemical Name | Probenecid |
| Elimination half-life | 2-6 hours (dose: 0.5-1 g) |
| Dosage (Strength) | 500mg |
| Pregnancy | Consult Doctor |
| Brands | Probenecid |
| Protein binding | 75-95% |
| PubChem CID | 4911 |
| MedlinePlus | a682395 |
| ChEBI | Not Assigned |
| ATC code | M04AB01 |
| DrugBank | DB01032 |
| KEGG | D00475 |
| Routes of administration | By mouth |
Standard Probenecid dosing is to take the medication orally 2x daily and with food or antacids to decrease the risk of stomach upset. Users should also drink a full glass of water with each dose and then at least another 8 ounces of water over the course of the day.
Do not start using Probenecid during a sudden or severe gout attack. Wait until the attack is over before starting to take the medication.
The active ingredient in Probenecid is Probenecid
Let your doctor know if you have any history of low blood count conditions like aplastic anemia, bone marrow depression, G6PD enzyme deficiency, kidney stones or obstruction, or peptic ulcer disease before starting on Probenecid
Your doctor may advise sodium bicarbonate or sodium citrate to counteract acidic urine resulting from the use of this medication
Probenecid is not a pain reliever and will not provide gout pain relief. Speak to your doctor and request a different pain reliever medication for gout if pain is unbearable.
Be aware of medication expiry date
Negative drug interactions may occur between Probenecid and other Rx medications, including celecoxib, ciprofloxacin, colchicine, ubiquinone, rosuvastatin, apixaban, empagliflozin, furosemide, escitalopram, atorvastatin, metoprolol, hydrocodone, amlodipine, acetaminophen, clopidogrel, montelukast, levothyroxine, acetaminophen, febuxostat, cyanocobalamin, rivaroxaban, sertraline, cetirizine.
Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Probenecid online.
Probenecid side effects may occur, and some users may experience headaches, dizziness, nausea, flushing, sore gums, increasing urination, or itching. If side effects are experienced, you may want to stop use and meet with a doctor again to discuss gout treatment medication alternatives.
How long until Probenecid users can expect to experience gout relief from the medication?
This time frame will depend on the user's age, physiology, and the extent of their gout or gouty arthritis. Most users will begin to experience relief within a week to 10 days of starting on the medication, but it is common for the improvements to be slow and gradual. Adjust your expectations accordingly.
What considerations need to be taken into account for gout sufferers prescribed this medication who also have peptic ulcer disease?
Patients with peptic ulcer disease should use Probenecid with caution because of a possible increase in gastrointestinal adverse reactions. If a person's dosage is too high, then gastric intolerance during the therapy may occur.
Are gout sufferers also more likely to get kidney stones because of this medication?
Yes, this is true and one of the strongest indicators of this possibility is seeing blood in the urine or back pain. This possibility usually occurs because the medication causes leakage of protein into the urine. If kidney stones occur because of Probenecid, it may be necessary to switch to another medication for gout treatment.
Are there interaction risks between Probenecid and NSAIDs (non-steroidal anti-inflammatory drugs)?
The only risk factor here is in instances where the person taking Probenecid had diminished kidney function. For anyone without kidney health concerns, there is no risk in using these types of anti-inflammatory medications while using Probenecid.
