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Ponvory (Ponesimod)

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Description

Ponvory (Ponesimod) is a selective sphingosine-1-phosphate receptor modulator that is primarily used for the treatment of adults with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. This prescription medication helps to reduce the frequency of MS flares and slow the progression of physical disability by controlling the immune system's response.

Ponvory works by binding to specific receptors on lymphocytes (a type of white blood cell), which helps prevent them from exiting lymph nodes and causing damage to the central nervous system. The drug has been evaluated in numerous clinical trials and has demonstrated effectiveness in reducing disease activity as seen on MRI scans, as well as reducing relapse rates. Before you buy Ponvory, it is crucial that you talk to your healthcare provider about potential side effects and Ponvory cost.

Buy Ponvory (Ponesimod) online from online Canadian Pharmacy | CanPharm.com

Directions

The recommended dosage of Ponvory is 20 mg taken orally once daily. Treatment should begin with a titration period over 14 days starting at 2 mg on the first day and gradually increasing to the full dose. This is crucial to help reduce the risk of cardiac effects from sudden heart rate reduction.

Ingredients

Active Ingredient: Ponesimod

Cautions

Use Ponvory with caution in patients with:

  • Cardiac issues, especially those who may be at increased risk of arrhythmias.
  • A history of uveitis; periodic eye examinations are recommended during treatment.
  • Liver impairment; dose adjustments may be required.
  • Active infections; treatment with Ponvory should be delayed until the infection is resolved.

Patients should inform their healthcare provider of any existing conditions, particularly those involving the heart, liver, or immune system, before starting treatment.

Interactions

Ponvory can interact with a variety of substances which can alter its effectiveness or increase the risk of side effects. These include:

  • Vaccines: Live attenuated vaccines should be avoided during and for up to 4 weeks after stopping treatment with Ponvory.
  • Other immunosuppressive drugs or immune-modulating therapies, which might enhance the immune system suppression.
  • CYP2C9 inhibitors or inducers can affect the metabolism of Ponvory and thus its efficacy and toxicity.

Patients should provide a complete list of all medications (prescription, over-the-counter, and herbal supplements) they are currently taking to their healthcare provider to prevent possible interactions.

Side Effects

Ponvory side effects may include:

  • Upper respiratory tract infections
  • Elevated liver enzymes
  • High blood pressure
  • Diarrhea
  • Hair loss

Frequently Asked Questions about Ponvory (Ponesimod)


What is Ponvory?

Ponvory is a brand name for the medication ponesimod, which is a prescription drug used to treat multiple sclerosis (MS).


What is Ponvory used for?

Ponvory is used to treat adults with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.


When was Ponvory approved?

Ponvory was approved by the U.S. Food and Drug Administration (FDA) on March 18, 2021.


What is the success rate of Ponvory?

The success rate of Ponvory can be measured by its efficacy in clinical trials. In a pivotal trial, Ponvory was shown to reduce the annualized relapse rate by 30.5% compared to teriflunomide, another MS medication.


What are the benefits of Ponvory?

The benefits of Ponvory include:

  • Reduction in the annualized relapse rate of MS.
  • Decrease in the number of new or enlarging brain lesions on MRI.
  • Improvement in delaying disability progression.

What is the active ingredient in Ponvory?

The active ingredient in Ponvory is ponesimod.


What is the function of ponesimod?

Ponesimod is a selective sphingosine-1-phosphate receptor modulator. It works by preventing lymphocytes (a type of white blood cell) from leaving the lymph nodes, thereby reducing their ability to enter the central nervous system and cause the inflammation that damages nerve cells in MS.


What are the side effects of ponesimod?

Common side effects of ponesimod include:

  • Upper respiratory tract infections
  • Elevated liver enzymes
  • High blood pressure
  • Shortness of breath
  • Headaches
  • Dizziness

What are the contraindications for Ponvory?

Ponvory should not be used in individuals with:

  • A history of heart attack, unstable angina, stroke, or certain types of heart failure in the past six months.
  • Certain types of heart block or sick sinus syndrome, unless they have a pacemaker.
  • Severe untreated sleep apnea.
  • Certain severe untreated infections.

What is the classification of ponesimod?

Ponesimod is classified as a sphingosine-1-phosphate (S1P) receptor modulator.