Also Known as Resotran
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Motegrity is a CIC and chronic idiopathic constipation treatment medication available by prescription. It works to increase the movement of the colon muscle (peristalsis) so that bowel movements occur more easily. The active ingredient in Motegrity is Prucalopride, a 5-HT4 agonist drug that targets a specific receptor in the colon to enhance the body's natural peristalsis process for waste elimination from the colon. You can buy Motegrity with a prescription here at Canpharm.
Fact Table | |
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Formula | C18H26ClN3O3 |
License | FDA approved |
Bioavailability | ~93% |
Legal status | Prescription Drug (Rx only) |
Chemical Name | 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)piperidin-4-yl]-7-benzofurancarboxamide |
Elimination half-life | ~24-30 hours |
Dosage (Strength) | 1 mg, 2 mg tablets |
Pregnancy | Consult Doctor (Category not classified) |
Brands | Motegrity |
Protein binding | ~30% |
PubChem CID | 3052763 |
MedlinePlus | a618021 |
ChEBI | CHEBI:85022 |
ATC code | A06AX05 |
DrugBank | DB09204 |
KEGG | D02568 |
Routes of administration | By mouth |
Standard dosage is to take 1 Motegrity tablet 1x day, with a meal or on its own.
The active ingredient in Motegrity is Prucalopride.
Let your doctor know of any history of kidney dysfunction, depression, suicidal thoughts or actions, or mood problems before starting on Motegrity
People who have blockages or tears in their stomach or intestinal wall may not be candidates for using Motegrity for CIC treatment
Women who are pregnant or plan to become pregnant should not use Motegrity unless their doctor approves it
Keep medication at room temperature in a dry place where it will not be exposed to moisture
Negative drug interactions may occur between Motegrity and other Rx or OTC medications, including amitriptyline, atorvastatin, baclofen, duloxetine, famotidine, gabapentin, levothyroxine, linaclotide, pregabalin, omeprazole, ondansetron, pantoprazole, prednisone, promethazine, tramadol, trazodone, and cetirizine. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Motegrity online.
Motegrity side effects may occur, and some users may experience headache, abdominal pain or bloating, nausea, diarrhea, dizziness, vomiting, or gas and fatigue. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss chronic constipation treatment medication alternatives.
How does Motegrity work?
Motegrity is a selective serotonin-4 (5-HT4) receptor agonist that enhances colonic peristalsis, the natural muscle contractions of the colon, to increase bowel motility and facilitate bowel movements.
What is the recommended dosage of Motegrity?
The typical dosage for adults is 2 mg taken orally once daily, with or without food. For patients with severe renal impairment (creatinine clearance less than 30 mL/min), the recommended dose is 1 mg once daily. Motegrity is not approved for use in children.
What are the common side effects of Motegrity?
Common side effects include headache, abdominal pain, nausea, diarrhea, dizziness, vomiting, gas, and fatigue. These side effects often occur at the start of therapy and typically diminish within a few days with continued treatment.
Are there any serious side effects associated with Motegrity?
Serious side effects may include unusual changes in mood or behavior, such as depression or suicidal thoughts. If you experience worsening depression, feelings of hopelessness, thoughts of suicide, or self-harm, stop taking Motegrity and contact your healthcare provider immediately.
Who should not take Motegrity?
Motegrity should not be used by individuals with:
Can Motegrity be used during pregnancy or breastfeeding?
There is limited data on the use of Motegrity during pregnancy. Animal studies have not shown adverse developmental effects, but it's unclear if these findings apply to humans. Prucalopride is present in breast milk, but its effects on the breastfed child or milk production are unknown. Consult your healthcare provider to weigh the potential benefits and risks before using Motegrity during pregnancy or while breastfeeding.
What should I do if I miss a dose of Motegrity?
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at one time to make up for a missed dose.
Can Motegrity interact with other medications?
There is no specific information available on drug interactions with Motegrity. However, always inform your healthcare provider about all the medications and supplements you are taking to ensure safety and avoid potential interactions.
How should Motegrity be stored?
Store Motegrity in its original container at room temperature, away from moisture and heat.
What should I discuss with my healthcare provider before starting Motegrity?
Inform your healthcare provider if you have a history of:
Additionally, discuss any other medications or supplements you are taking to ensure Motegrity is safe and appropriate for you.
Always consult your healthcare provider for personalized medical advice before starting any new medication.