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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Lapelga, with the active ingredient pegfilgrastim, is a biologic medication designed to support cancer patients undergoing chemotherapy. It belongs to a class of drugs known as colony-stimulating factors. Pegfilgrastim is a long-acting form of the human granulocyte colony-stimulating factor (G-CSF), which is essential to produce white blood cells (neutrophils). Lapelga is specifically used to prevent infections by increasing white blood cells, reducing the incidence of febrile neutropenia, a common and severe side effect of some chemotherapeutic agents.
Before you buy Lapelga, it is crucial that you talk to your healthcare provider about potential side effects and Lapelga cost.
| Fact Table | |
|---|---|
| Formula | C845H1343N223O243S9 |
| License | FDA approved |
| Bioavailability | High (subcutaneous) |
| Legal status | Prescription Drugs |
| Chemical Name | Pegfilgrastim |
| Elimination half-life | 15 to 80 hours |
| Dosage (Strength) | 6 mg/0.6 mL |
| Pregnancy | Consult healthcare provider |
| Brands | Lapelga |
| Protein binding | Not applicable |
| PubChem CID | 91914851 |
| MedlinePlus | Not listed specifically |
| ChEBI | Not available |
| ATC code | L03AA13 |
| DrugBank | DB00019 (Pegfilgrastim) |
| KEGG | D06377 |
| Routes of administration | Subcutaneous |
Lapelga is administered as a subcutaneous injection. It is typically given once per chemotherapy cycle, no sooner than 24 hours after the last dose of chemotherapy and at least 14 days before the beginning of the next cycle. The standard dosage is a single 6 mg injection for adults. However, dosage may vary based on body weight, the specific chemotherapy regimen, and the patient’s medical history. Always follow the prescription provided by your healthcare provider and consult them before making any changes to your medication schedule.
The primary active ingredient in Lapelga is pegfilgrastim.
Inform your doctor if you have had any allergic reactions to pegfilgrastim, filgrastim, or any other part of this drug.
Patients with sickle cell disorders should use this medication cautiously as it can potentially cause severe sickle cell crises.
Discuss with your healthcare provider if you are pregnant, planning on becoming pregnant, or breastfeeding. The effects of pegfilgrastim on the fetus or newborn are not fully known.
Those with kidney disease may require adjusted doses and closer monitoring.
Lapelga injection can interact with other medications, potentially altering their effects. Before starting treatment, inform your healthcare provider about all the medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements. Specifically, drugs that stimulate white blood cell production or those that affect blood cell proliferation should be monitored closely.
While Lapelga is effective in preventing infections during chemotherapy, it may cause side effects in some patients. Common side effects include:
What is Lapelga used for?
Lapelga is a medication commonly used as a long-acting insulin analog. It is typically prescribed to improve blood sugar control in adults and children with diabetes mellitus. Lapelga helps to lower blood sugar levels by enabling the glucose in the blood to enter cells, thus providing them with the energy they need and preventing high blood sugar levels.
How long do Lapelga side effects last?
The duration of side effects from Lapelga can vary depending on the type of side effect and the individual. Common side effects like hypoglycemia (low blood sugar), pain at the injection site, or allergic reactions are usually temporary. Hypoglycemia can occur immediately and may require quick management, while local reactions at the injection site typically resolve within a few days. Always consult a healthcare provider if side effects persist or cause significant discomfort.
How long does it take for Lapelga to work?
Lapelga, as a long-acting insulin, typically begins to work several hours after injection and can last up to 24 hours. The onset of action generally occurs around 1 to 2 hours post-injection. However, the full benefits in blood sugar control might be observed over a period of a few days to weeks as the body adjusts to the insulin. Consistent use as prescribed by a healthcare provider is crucial for optimal effectiveness.
What are the common side effects of Lapelga?
Common side effects of Lapelga include hypoglycemia (low blood sugar), injection site reactions (such as redness, swelling, or pain), and allergic reactions. Other side effects may include weight gain, swelling in the hands or feet, and skin thickening or pitting at the injection site. It's important to report any unusual or severe side effects to your healthcare provider.
Can Lapelga be used during pregnancy?
Lapelga can be used during pregnancy if deemed necessary by a healthcare provider. Managing blood sugar levels is crucial during pregnancy to avoid complications for both the mother and the baby. Pregnant women should work closely with their healthcare provider to ensure proper dosing and monitoring while using Lapelga.
How should Lapelga be stored?
Lapelga should be stored in the refrigerator between 36°F and 46°F (2°C to 8°C) until its expiration date. Once opened, it can be kept at room temperature below 86°F (30°C) for up to 28 days. Do not freeze Lapelga or expose it to direct sunlight or high heat. Always check the product label for specific storage instructions.
What should I do if I miss a dose of Lapelga?
If you miss a dose of Lapelga, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take extra doses to make up for the missed one. Always consult your healthcare provider for specific instructions if you miss a dose.
Can Lapelga be taken with other diabetes medications?
Lapelga can often be used in combination with other diabetes medications, such as rapid-acting insulin or oral medications, to achieve better blood sugar control. However, it is essential to follow your healthcare provider's guidance on combining medications to avoid adverse effects and interactions.
How do I know if Lapelga is working for me?
Regular monitoring of blood sugar levels is crucial to determine if Lapelga is effectively managing your diabetes. Your healthcare provider may also conduct periodic HbA1c tests to assess your average blood sugar levels over the past few months. Consistent blood sugar readings within your target range and a stable HbA1c level indicate that Lapelga is working effectively.
What should I do in case of an overdose of Lapelga?
An overdose of Lapelga can lead to severe hypoglycemia (low blood sugar). Symptoms may include sweating, dizziness, confusion, shaking, and fainting. If you suspect an overdose, consume a fast-acting source of sugar (like glucose tablets or juice) and seek immediate medical attention. Always keep a glucagon kit available and inform those around you on how to use it in case of an emergency.
