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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Jadenu is an iron overload treatment medication used to reduce blood iron levels for people with thalassemia syndrome. It may also be prescribed for people who have high blood iron levels because of multiple blood transfusion being required because of sickle cell anemia or another type of similar condition. Deferasirox is an iron-chelating agent drug that binds to iron and then forces it to be passed out of the body via waste elimination. You can buy Jadenu with a prescription here at Canpharm.
| Fact Table | |
|---|---|
| Formula | C21H15N3O4 |
| License | FDA approved |
| Bioavailability | ~70% (higher with the Jadenu formulation compared to Exjade) |
| Legal status | Prescription Drug |
| Chemical Name | 4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid |
| Elimination half-life | ~8-16 hours |
| Dosage (Strength) | 90mg, 180mg, 360mg film-coated tablets |
| Pregnancy | Consult Doctor (Category C) |
| Brands | Jadenu, Exjade |
| Protein binding | ~99% (mostly bound to albumin) |
| PubChem CID | 16682541 |
| MedlinePlus | a607042 |
| ChEBI | 82662 |
| ATC code | V03AC03 |
| DrugBank | DB01609 |
| KEGG | D03652 |
| Routes of administration | By mouth |
Standard dosage for Jadenu medication is to take it 1x daily with food on an empty stomach or only having eaten a light meal beforehand. Taking with high calorie meals may increase the likelihood of side effects.
The active ingredient in Jadenu is Deferasirox
Let your doctor know of any history of cancer, kidney or liver disease, low blood platelet counts, or bone marrow disorders before starting on Jadenu
Avoid taking this medication with antacids that contain aluminum
Use of this medication may make you dizzy or drowsy and it may be advisable to avoid driving or operating machinery
Children or older adults may be more susceptible to side effects from Jadenu generic
Women who are pregnant or breastfeeding should only use this medication if their doctor approves it
Negative drug interactions may occur between Jadenu and other Rx or OTC medications, including tocilizumab, everolimus, amitriptyline, darbepoetin alfa, baclofen, sulfamethoxazole, trimethoprim, diphenhydramine, bosutinib, citalopram, clindamycin, apixaban, furosemide, gabapentin, imatinib, hydroxyurea, ruxolitinib, metformin, filgrastim, pantoprazole, eltrombopag, quetiapine, and trazodone. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Jadenu online
Jadenu side effects may occur and some users may experience nausea, vomiting, dizziness, hearing loss, or vision changes. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss thalassemia treatment medication alternatives.
What is Jadenu used for?
Jadenu (deferasirox) is used to treat chronic iron overload, often due to blood transfusions, in patients with conditions like thalassemia or sickle cell disease.
How does Jadenu work?
Jadenu works by binding to excess iron in the body and helping to remove it through the urine, reducing the risk of iron buildup in vital organs.
How should Jadenu be taken?
Jadenu should be taken once daily, preferably on an empty stomach, by dissolving the tablet in water or fruit juice as directed by your doctor.
What are the side effects of Jadenu?
Common side effects include gastrointestinal issues like nausea, diarrhea, and abdominal pain, as well as skin rashes. Serious side effects may include liver damage and kidney problems.
How long does it take for Jadenu to work?
Jadenu may start to show a reduction in iron levels within weeks, but it may take several months for the full benefits to be seen.
Who should not take Jadenu?
Jadenu should not be taken by people with severe kidney or liver problems or by those who are allergic to deferasirox or any of the ingredients in the medication.
Can Jadenu cause kidney problems?
Yes, Jadenu can cause kidney toxicity, so kidney function should be monitored regularly during treatment.
How should Jadenu be stored?
Jadenu should be stored at room temperature, away from moisture and heat, and kept out of the reach of children.
Can I take Jadenu with other medications?
Jadenu may interact with other medications, especially those affecting the liver or kidneys. Always inform your doctor of all medications you're taking.
Can I stop taking Jadenu suddenly?
Do not stop taking Jadenu suddenly without consulting your doctor, as discontinuing the medication could lead to dangerous iron overload.
