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Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Estrofem is a postmenopausal treatment medication that is used for HRT (hormone replacement) therapy for women suffering from more pronounced estrogen deficiency after menopause. It may also be prescribed for women of any age who have the same deficiency because of a hysterectomy. Estradiol is a synthetic replacement for estrogen and by using it women can regain a better level of it and experience less of the hot flashes, night sweats, sleeplessness, urinary problems, vaginal dryness, headaches, and mood swings that come with estrogen deficiency. You can buy Estrofem with a prescription here at Canpharm.
| Fact Table | |
|---|---|
| Formula | C18H24O2 |
| License | FDA and EMA approved |
| Bioavailability | ~5% (oral, due to first-pass metabolism); higher with transdermal or vaginal routes |
| Legal status | Prescription Drug |
| Chemical Name | (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
| Elimination half-life | ~13-20 hours |
| Dosage (Strength) | 1mg, 2mg oral tablets |
| Pregnancy | Contraindicated |
| Brands | Estrofem, Estrace, Climara, Estraderm |
| Protein binding | 95-98% (bound to albumin and sex hormone-binding globulin) |
| PubChem CID | 5757 |
| MedlinePlus | a604032 |
| ChEBI | 16469 |
| ATC code | G03CA03 |
| DrugBank | DB00783 |
| KEGG | D00102 |
| Routes of administration | By mouth, Transdermal, Vaginal, Injection |
Standard Estrofem dosage for this medication is to take one 2mg tablet each day, and ideally at the same time each day until all 28 tablets in the pack are finished. Always take your medication exactly as indicated in your prescription.
To use the Estrofem calendar pack:
The active ingredient in Estrofem is Estradiol
Let your doctor know of any history of heart or kidney disease, cancer, systemic lupus erythematosus, blood clots, pancreas inflammation, angioedema, epilepsy, diabetes, asthma, gallstones, or otosclerosis before starting on Estrofem 2mg
Use of this medication may not be possible for people with lactose intolerance
Be aware of medication expiry date
Negative drug interactions may occur between Estrofem and other Rx or OTC medications, including phenytoin, carbamazepine, rifampicin, rifabutin, nevirapine, efavirenz, ritonavir, nelfinavir, and St. John's Wort. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Estrofem online.
Estrofem side effects may occur and some users may experience jaundice (skin yellowing), raised blood pressure, headaches, or vision problems. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss postmenopausal hormone replacement therapy medication alternatives.
What is Estrofem used for?
Estrofem (estradiol) is used as hormone replacement therapy (HRT) to relieve menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis prevention.
How does Estrofem work?
Estrofem provides estradiol, a form of estrogen, to compensate for the decline in natural estrogen levels during menopause.
How should Estrofem be taken?
Take Estrofem once daily, preferably at the same time each day, with or without food, as directed by your doctor.
How long does Estrofem take to work?
Some symptom relief may be noticed within a few days to weeks, but full benefits may take a few months.
What are the side effects of Estrofem?
Common side effects include nausea, headache, breast tenderness, bloating, mood changes, and spotting or breakthrough bleeding.
Who should not take Estrofem?
Estrofem should not be used by women with a history of breast cancer, blood clots, untreated endometrial hyperplasia, or severe liver disease.
Can Estrofem increase the risk of blood clots?
Yes, Estrofem may increase the risk of blood clots, stroke, and heart disease, especially in smokers or those with existing risk factors.
Does Estrofem cause weight gain?
Weight gain can occur due to fluid retention, but lifestyle factors also play a role in weight changes.
Can Estrofem be used long-term?
Long-term use should be evaluated by a doctor, balancing benefits against risks such as cardiovascular disease and cancer.
What should be avoided while taking Estrofem?
Avoid smoking, excessive alcohol, and grapefruit juice, as they may affect hormone metabolism and increase side effects.
