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Daraprim (Pyrimethamine)

Prescription requiredOnly Available By Prescription
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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Daraprim is a toxoplasmosis treatment medication that may also be prescribed to treat malaria or cystoisosporiasis infection. Daraprim uses may also be for people with HIV infection who are more at risk for toxoplasmosis. Pyrimethamine is an aminopyridine derivate parasiticide drug that will effectively eliminate the parasites and prevent the infection from worsening. It will usually be used alongside Leucovorin to minimize side effects for users while still ensuring the parasitic infection is ended. You can buy Daraprim with a prescription here at Canpharm.

Fact Table
Formula C12H13ClN4
License FDA approved
Bioavailability ~90%
Legal status Prescription Drug
Chemical Name 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
Elimination half-life ~96 hours
Dosage (Strength) 25mg tablets
Pregnancy Use with caution; consult doctor (Category C)
Brands Daraprim
Protein binding ~87%
PubChem CID 4993
MedlinePlus a682231
ChEBI 8673
ATC code P01BD01
DrugBank DB00205
KEGG D08474
Routes of administration By mouth

Buy Daraprim (Pyrimethamine) online from online Canadian Pharmacy | CanPharm.com

Directions

Standard dosage for this medication is to take one tablet 1 or 2x daily. Take your medication exactly as indicated in your prescription.

Ingredients

The active ingredient in Daraprim is Pyrimethamine

Cautions

Let your doctor know of any history of liver or kidney problems, seizures, megaloblastic anemia, low folic acid levels, low red or white blood cell counts, or low blood platelet counts before starting on Daraprim

People with certain surgeries scheduled in the near future may not be candidates to use Daraprim until after their surgery and a possible recovery time

Women who are pregnant or breastfeeding should not use this medication unless their doctor approves it because of the risk of depleted folic acid levels

Use of this medication may slow the removal of other medications from your body

Store at room temperature away from light and moisture and be aware of medication expiry date

Interactions

Negative drug interactions may occur between Daraprim and other Rx or OTC medications, including auronofin, aurothioglucose, deferiprone, glucarpidase, sodium thiomalate, kaolin, magaldrate, methotrexate, pralatrexate, proguanil, sapropterin, sulfadiazine, sulfamethoxazole, sulfasalazine, trimethoprim, trimetrexate, and zidovudine. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Daraprim online.

Side Effects

Daraprim side effects may occur, and some users may experience nausea, vomiting, appetite loss, sore throat, fever, or fatigue. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss parasitic infection treatment medication alternatives and a pharmacist for a lower Daraprim price.

Frequently Asked Questions about Daraprim (Pyrimethamine)


What is Daraprim used for?

Daraprim (pyrimethamine) is used to treat and prevent parasitic infections, such as toxoplasmosis and malaria.


How does Daraprim work?

Daraprim works by inhibiting the activity of the enzyme dihydrofolate reductase, which is necessary for the growth of certain parasites, thus preventing their replication.


How should Daraprim be taken?

Daraprim is typically taken orally with food, as directed by your doctor. The dosage depends on the condition being treated and may vary for different patients.


What are the side effects of Daraprim?

Common side effects include nausea, vomiting, abdominal pain, rash, and fever. Serious side effects can include blood disorders, liver problems, and allergic reactions.


How long does it take for Daraprim to work?

The effectiveness of Daraprim can vary depending on the infection. It may take a few days to weeks to start noticing improvement, and treatment may last several weeks depending on the condition.


Who should not take Daraprim?

Daraprim should not be used by individuals who are allergic to pyrimethamine or any of its components, or those with pre-existing blood disorders like megaloblastic anemia.


Can Daraprim interact with other medications?

Yes, Daraprim can interact with other medications, such as folic acid supplements, certain antiepileptic drugs, and other medications affecting bone marrow function.


Can Daraprim cause low blood cell counts?

Yes, one of the serious side effects of Daraprim is bone marrow suppression, which can lead to low white blood cell or red blood cell counts (anemia, leukopenia, or thrombocytopenia).


How should Daraprim be stored?

Store Daraprim at room temperature, away from moisture, light, and heat, and keep it out of the reach of children.


Can I stop taking Daraprim suddenly?

It is important to complete the full course of Daraprim as prescribed to ensure the infection is fully treated. Stopping the medication prematurely can lead to treatment failure or a relapse of the infection.