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Cuprimine (Penicillamine)

Also Known as Distamine

Prescription requiredOnly Available By Prescription
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What is Generic?

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What is a Generic Drug?

A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.

The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.

Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.

Description

Cuprimine is a rheumatoid arthritis treatment medication that may also be used to treat Wilson’s disease or cystinuria. Penicillamine is a DMARD (disease-modifying antirheumatic drug) that reduces the level of swelling, tenderness, and pain experienced in arthritic joints, but it can also serve as a chelating-agent drug to bind to copper for Wilson’s disease treatment. For cystinuria treatment Cuprimine can be used to decrease cystine in the urine so there is less of a chance of kidney stones. You can buy Cuprimine with a prescription here at Canpharm.

Fact Table
Formula C5H11NO2S
License FDA approved
Bioavailability 40-70%
Legal status Prescription Drugs
Chemical Name D-penicillamine
Elimination half-life 1-3 hours
Dosage (Strength) 250mg
Pregnancy Consult Doctor (Category D in the US)
Brands Cuprimine, Depen
Protein binding Negligible
PubChem CID 922
MedlinePlus a682022
ChEBI 5830
ATC code M01CC01
DrugBank DB00859
KEGG D08367
Routes of administration By mouth

Buy Cuprimine (Penicillamine) online from online Canadian Pharmacy | CanPharm.com

Directions

Standard dosage for Cuprimine is to take the medication 1x daily and one hour before a meal or two hours after one. Also be sure to take this medication at least 1 hour after or before you ingest milk, any food or supplement containing zinc, or taking an antacid.

It is best to take this medication at the same time every day

If Cuprimine is being used for Wilson's disease it is essential for the patient to adhere to dietary changes in order for the medication to be effective

Ingredients

The active ingredient in Cuprimine is Penicillamine

Cautions

Let your doctor know of any history of kidney disease, aplastic anemia, agranulocytosis, or blood and bone marrow disorders like thrombocytopenia before starting on Cuprimine

Individuals who have surgery scheduled in the near future may not be able to start on this medication until after their surgery

Women who are pregnant or plan to become pregnant should not use Cuprimine generic unless their doctor approves it

Be aware of medication expiry date

Interactions

Negative drug interactions may occur between Cuprimine and other Rx or OTC medications, including digoxin, auranofin, chloroquine, phenylbutazone, azathioprine, trimethoprim, and sulfamethoxazole. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Cuprimine online.

Side Effects

Cuprimine side effects may occur, and some users may experience nausea, vomiting, diarrhea, stomach pain, appetite loss, skin blisters, or a loss of taste. If side effects are experienced you may want to discontinue use and meet with a doctor again to discuss rheumatoid arthritis treatment medication alternatives.

Frequently Asked Questions about Cuprimine


What is Cuprimine used for?

Cuprimine is prescribed for:

  • Wilson's Disease: A genetic disorder leading to excessive copper accumulation in the body. Cuprimine binds to the excess copper, facilitating its removal.
  • Cystinuria: A condition characterized by high levels of cystine in the urine, leading to kidney stones. Cuprimine helps reduce cystine levels, preventing stone formation.
  • Severe Rheumatoid Arthritis: For patients who have not responded to other treatments, Cuprimine can help reduce pain, tenderness, and swelling in the joints.

How should I take Cuprimine?

Cuprimine should be taken orally on an empty stomach, at least one hour before or two hours after meals. It's important to take it at the same time(s) each day and to follow your doctor's dosing instructions carefully. Avoid taking it simultaneously with other medications, food, milk, antacids, or products containing iron or zinc, as these can interfere with absorption.


What are the common side effects of Cuprimine?

Common side effects may include:

  • Stomach or abdominal pain
  • Nausea or vomiting
  • Loss of appetite
  • Diarrhea
  • Decreased sense of taste

If any of these effects persist or worsen, contact your doctor promptly.


Are there serious side effects I should be aware of?

Yes, Cuprimine can cause serious side effects, including:

  • Signs of infection (e.g., persistent sore throat, fever)
  • Easy bruising or bleeding
  • New or worsening joint pain
  • Muscle weakness
  • Eye problems (e.g., drooping eyelids, blurred vision)

Seek immediate medical attention if you experience any of these symptoms.


Can I take Cuprimine during pregnancy or while breastfeeding?

Cuprimine can harm an unborn baby and is generally not recommended during pregnancy, especially for treating cystinuria or rheumatoid arthritis. However, in certain situations like Wilson's disease, the benefits may outweigh the risks. Breastfeeding is not recommended while using this medication due to potential risks to the infant.


What precautions should I take while using Cuprimine?

  • Regular Monitoring: Your doctor will likely schedule regular blood and urine tests to monitor your response and check for side effects.
  • Avoid Certain Supplements: Do not take iron or vitamin supplements containing iron within two hours of taking Cuprimine, as they can interfere with its effectiveness.
  • Inform Healthcare Providers: Before any surgery or dental work, inform your healthcare provider that you're taking Cuprimine.

Are there any drug interactions with Cuprimine?

Cuprimine can interact with certain medications, including:

  • Gold therapy products
  • Antimalarial medications
  • Cancer chemotherapy drugs
  • Phenylbutazone

Inform your doctor about all the medications and supplements you're taking to avoid potential interactions.


What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it's near the time of the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.


How should I store Cuprimine?

Store Cuprimine at room temperature, away from light and moisture. Keep it out of reach of children and do not store it in the bathroom.


Can Cuprimine cause allergic reactions?

Yes, some individuals may experience allergic reactions to Cuprimine, including rash, itching, swelling, severe dizziness, or trouble breathing. Seek immediate medical attention if you notice any signs of a serious allergic reaction.


Always consult your healthcare provider for personalized medical advice regarding Cuprimine.