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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Comtan is a Parkinson’s disease treatment medication used to reduce the severity of tremors, muscle stiffness, slowed movement, and impaired that comes with Parkinson’s. Entacapone is a catechol-O-methyltransferase inhibitor drug and it is almost used in conjunction with a Levodopa medication because Comtan slows the breakdown of Levodopa and extends its effects. You can buy Comtan with a prescription here at Canpharm.
| Fact Table | |
|---|---|
| Formula | C14H15N3O5 |
| License | FDA approved |
| Bioavailability | ~35% |
| Legal status | Prescription Drug |
| Chemical Name | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide |
| Elimination half-life | ~0.4–0.7 hours |
| Dosage (Strength) | 200mg tablets |
| Pregnancy | Use with caution; consult doctor (Category C) |
| Brands | Comtan |
| Protein binding | ~98% |
| PubChem CID | 5281088 |
| MedlinePlus | a601236 |
| ChEBI | 4792 |
| ATC code | N04BX02 |
| DrugBank | DB00494 |
| KEGG | D07854 |
| Routes of administration | By mouth |
Standard dosage is take one Comtan 200mg tablet daily and at the same time each day. Dosage strength and frequency may vary and you should always take medication exactly as indicated in your prescription.
The active ingredient in Comtan is Entacapone
Let your doctor know of any history of hypotension (low blood pressure), dyskinesia, liver dysfunction, schizophrenia, delusional disorder, sleep apnea, narcolepsy, or compulsion disorders before starting on Comtan
Use of this medication may discolor urine and this is normal and not a cause for concern
Use of this medication may make you drowsy or dizzy
Keep medication in a secure location and out of the reach of children
Be aware of medication expiry date
Negative drug interactions may occur between Comtan and other Rx or OTC medications, including baclofen, carbidopa, citalopram, clonazepam, duloxetine, gabapentin, pramipexole, quetiapine, sertraline, and trazodone. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Comtan online.
Comtan side effects may occur, and some users may experience diarrhea, nausea, stomach pain, vomiting, dry mouth, changes to urine color, or involuntary movements. If side effects are seen you may want to discontinue use and meet with a doctor again to discuss Parkinson’s treatment medication alternatives and a pharmacist for a lower Comtan cost.
What is Comtan used for?
Comtan (entacapone) is used in combination with levodopa to treat symptoms of Parkinson’s disease, particularly to improve motor control and reduce "off" time when symptoms worsen.
How does Comtan work?
Comtan works by inhibiting the enzyme catechol-O-methyltransferase (COMT), which breaks down dopamine, thus increasing the availability of dopamine in the brain and enhancing the effects of levodopa.
How should Comtan be taken?
Comtan is usually taken orally with each dose of levodopa, typically 3 times a day with meals. The dosage is adjusted based on individual response and doctor’s recommendations.
What are the side effects of Comtan?
Common side effects include nausea, diarrhea, dizziness, and changes in urine color (it may turn reddish-brown). Serious side effects may include liver problems and severe dyskinesia (involuntary movements).
How long does it take for Comtan to work?
Comtan works quickly to increase the effectiveness of levodopa, and improvements in motor function may be seen within a few days to weeks.
Who should not take Comtan?
Comtan should not be used by individuals with liver problems, those who are taking nonselective monoamine oxidase inhibitors (MAOIs), or people with a history of hypersensitivity to entacapone.
Can Comtan interact with other medications?
Yes, Comtan can interact with other medications, particularly levodopa and other Parkinson's disease medications, as well as certain antidepressants and blood pressure medications. Always inform your doctor of all the medications you are taking.
Can Comtan cause changes in urine color?
Yes, one of the common side effects of Comtan is that it can cause urine to turn reddish-brown, which is harmless but may be alarming to some users.
How should Comtan be stored?
Store Comtan at room temperature, away from light and moisture, and keep it out of the reach of children.
Can I stop taking Comtan suddenly?
Stopping Comtan suddenly is not recommended, as it could lead to a sudden worsening of Parkinson's symptoms. Always consult your doctor before discontinuing or adjusting the medication.
