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Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Combigan is an ocular hypertension treatment medication prescribed for people with glaucoma or other conditions where there is excessive fluid pressure on the optic nerve of the eye. Brimonidine is an alpha-2 adrenergic agonist drug that reduces the amount of fluid in the eye and Timolol is a beta-blocker that limits increases in intraocular pressure by reducing aqueous humor in the eyeball. You can buy Combigan eye drops with a prescription here at Canpharm.
| Fact Table | |
|---|---|
| Formula | Brimonidine: C11H10BrN5 Timolol: C13H24N4O3S |
| License | FDA approved |
| Bioavailability | Minimal systemic absorption (ocular use) |
| Legal status | Prescription Drug |
| Chemical Name | **Brimonidine:** 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine **Timolol:** (S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol |
| Elimination half-life | Brimonidine: ~2 hours Timolol: ~4–6 hours |
| Dosage (Strength) | Brimonidine 0.2% / Timolol 0.5% ophthalmic solution |
| Pregnancy | Use with caution; consult doctor |
| Brands | Combigan |
| Protein binding | Brimonidine: ~29% Timolol: ~60% |
| PubChem CID | Brimonidine: 60953 Timolol: 33624 |
| MedlinePlus | a607065 |
| ChEBI | Brimonidine: 3176 Timolol: 9555 |
| ATC code | S01ED51 |
| DrugBank | Brimonidine: DB00484 Timolol: DB00373 |
| KEGG | Brimonidine: D00692 Timolol: D08697 |
| Routes of administration | Ophthalmic (eye drops) |
Standard dosage guidelines for Combigan eye drops is to place 1 drop into affected eyeballs 2x daily, with doses spaced 12 hours apart
The active ingredients in Combigan are Brimonidine and Timolol
Let your doctor know of any history of COPD, asthma, heart failure, slow heartbeat, stroke, blood clots, high or low blood pressure, Raynaud's syndrome, diabetes, thyroid disorder, myasthenia gravis, or depression before starting on Combigan eye drops
Not for use with children under the age of 2
Do not use medication remaining in Combigan generic eye dropper if it is longer than 28 days after opening it due to the risk of bacteria forming and being transferred into the eye
Women who are pregnant or breastfeeding should only use this medication if a doctor approves it
Negative drug interactions may occur between Combigan and other Rx or OTC medications, including amlodipine, furosemide, gabapentin, hydrochlorothiazide, lisinopril, losartan, metoprolol, rosuvastatin, simvastatin, tamsulosin, and tramadol. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Combigan eye drops online.
Combigan drops side effects may occur, and some users may experience slowed or accelerated heart rate, shallow breathing, eye swelling or redness, eye pain, eye watering or numbness or a tingling feeling in hands or feet. If side effects are seen it may be best to discontinue use and meet with a doctor to discuss open-angle glaucoma treatment medication alternatives.
What is Combigan?
Combigan is a prescription eye drop that contains brimonidine (alpha agonist) and timolol (beta-blocker). It is used to lower eye pressure in patients with glaucoma or ocular hypertension.
What is Combigan used for?
Combigan is primarily used to reduce intraocular pressure (IOP) in people with open-angle glaucoma or ocular hypertension to help prevent vision loss.
How long can you use Combigan eye drops?
Combigan is safe for long-term use under a doctor’s supervision. Regular eye pressure check-ups are needed to monitor effectiveness and potential side effects.
Do Combigan eye drops need to be refrigerated?
No, Combigan does not require refrigeration. It should be stored at room temperature (59-77°F or 15-25°C) in a dry place, away from light.
How does Combigan work?
Combigan works by:
Together, these help reduce intraocular pressure (IOP) and prevent optic nerve damage.
How long does Combigan stay in your system?
How long does it take for Combigan to work?
Combigan starts lowering eye pressure within 1–2 hours after application, with peak effects around 2–6 hours.
How to use Combigan eye drops?
Is Combigan a beta-blocker?
Yes, Combigan contains timolol, which is a beta-blocker that reduces fluid production in the eye to lower pressure.
Is Combigan a steroid?
No, Combigan is not a steroid. It contains an alpha agonist (brimonidine) and a beta-blocker (timolol) to reduce intraocular pressure.
