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Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Calquence is a leukemia treatment medication used for treatment of 3 different types of leukemia cancers – mantle cell leukemia, chronic lymphocytic leukemia, and small lymphocytic lymphoma. Acalabrutinib is a kinase inhibitor drug and it prevents the growth of cancer cells by blocking the Bruton tyrosine kinase protein. Calquence may prescribed for patients who have insufficient results from other treatment medications when treating non-Hodgkin’s lymphoma. You can buy Calquence with a prescription here at Canpharm.
| Fact Table | |
|---|---|
| Formula | C26H23N7O2 |
| License | FDA approved |
| Bioavailability | ~25% |
| Legal status | Prescription Drug |
| Chemical Name | 4-[(3R)-3-[8-Amino-3-(2-butyn-1-yl)-2-methylimidazo[1,5-a]pyrazin-1-yl]-1-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-7-one |
| Elimination half-life | ~1 hour |
| Dosage (Strength) | 100mg capsules |
| Pregnancy | Contraindicated (may cause fetal harm) |
| Brands | Calquence |
| Protein binding | ~97.5% |
| PubChem CID | 71271230 |
| MedlinePlus | a617024 |
| ChEBI | 145816 |
| ATC code | L01EL02 |
| DrugBank | DB11736 |
| KEGG | D10897 |
| Routes of administration | By mouth |
Standard dosage is one Calquence 100mg tablet taken twice daily every 12 hours, and taken with or without food
The active ingredient in Calquence is Acalabrutinib
Let your doctor know of any history of heart rhythm problems, serious infections, liver problems including HBV infection, or planned surgery before starting on Calquence
Calquence may increase excessive bleeding risks if you are using a blood thinner medication
Use of proton pump inhibitor antacid medications may not be suitable while using Calquence
Women able to conceive and taking Calquence should use some form of birth control for at least 1 week after their last dose of this medication
Negative drug interactions may occur between Calquence and other Rx or OTC medications, including itraconazole and rifampin. Let your doctor know of all medications you are currently taking before getting a prescription and proceeding to buy Calquence online.
Calquence side effects may occur, and some users may experience upper respiratory infections, headache, diarrhea, muscle or joint pain, or bruising. If Calquence side effects are seen you may want to discontinue use and meet with a doctor again to discuss leukemia treatment medication alternatives.
What is Calquence used for?
Calquence (acalbrutinib) is used to treat certain types of blood cancers, including chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).
How does Calquence work?
Calquence is a Bruton's tyrosine kinase (BTK) inhibitor. It works by blocking the BTK enzyme, which is involved in the signaling of cancerous B cells, thereby inhibiting their growth and survival.
What happens when you stop taking Calquence?
If you stop taking Calquence, the progression of your blood cancer may resume, and the symptoms may worsen. It is important to consult your doctor before discontinuing it, as stopping treatment abruptly could reduce its effectiveness.
Can you drink alcohol with Calquence?
There is no known direct interaction between alcohol and Calquence, but it is advisable to limit alcohol intake while on cancer treatments. Alcohol can affect your immune system and liver function, so it's best to consult your doctor regarding alcohol consumption.
Does Calquence cause weight gain?
Weight gain is not a common side effect of Calquence. However, side effects can vary, and some people may experience changes in appetite or fluid retention, which could lead to weight changes.
How effective is Calquence?
Calquence has shown significant effectiveness in treating CLL and SLL, helping to reduce the number of cancerous B cells and improving patient outcomes. Its effectiveness can vary based on individual cases and treatment response.
How long can you take Calquence?
The duration of treatment with Calquence depends on the specific condition and response to therapy. It is often taken long-term, but your doctor will determine the appropriate treatment duration based on your response and any side effects.
What are the side effects of Calquence?
Common side effects of Calquence include headache, diarrhea, bruising, fatigue, and upper respiratory infections. Serious side effects can include bleeding, heart problems, and infections. It's important to report any unusual symptoms to your healthcare provider.
What not to take with Calquence?
You should avoid taking strong CYP3A inhibitors (like ketoconazole or itraconazole) or strong CYP3A inducers (like rifampin) with Calquence, as these can affect how the drug is metabolized. Always inform your doctor of any other medications or supplements you're taking.
