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Only Available By Prescription
A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Avastin (Bevacizumab) is a prescription medication used primarily to treat various forms of cancer, including colorectal, lung, glioblastoma, kidney, and ovarian cancer. It is classified as a monoclonal antibody and functions as an angiogenesis inhibitor, which means it helps prevent the growth of new blood vessels that tumors need to grow and spread. Avastin works by targeting and inhibiting the function of a natural protein called vascular endothelial growth factor (VEGF) that stimulates new blood vessel formation in the body. By blocking this protein, Avastin can decrease the supply of nutrients and oxygen to the tumor, thereby inhibiting tumor growth.
This medication is usually administered in combination with other cancer therapies as part of a comprehensive treatment plan. Avastin is given intravenously, which means it is injected into a vein through an IV. Before you buy Avastin, it is crucial that you talk to your healthcare provider about potential side effects and Avastin cost.
| Fact Table | |
|---|---|
| Formula | C6638H10160N1720O2108S44 |
| License | FDA approved |
| Bioavailability | Intravenous only |
| Legal status | Prescription only |
| Chemical Name | Bevacizumab |
| Elimination half-life | Approximately 20 days |
| Dosage (Strength) | 100 mg or 400 mg vials |
| Pregnancy | Contraindicated; should not be used during pregnancy |
| Brands | Avastin |
| Protein binding | High (IgG1 antibody) |
| PubChem CID | Not available |
| MedlinePlus | a607002 |
| ChEBI | 71226 |
| ATC code | L01XC07 |
| DrugBank | DB00112 |
| KEGG | D03257 |
| Routes of administration | Intravenous |
Preparation and Administration:
Avastin should be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents. The medication is delivered intravenously over 90 minutes for the first infusion. If the first infusion is tolerated well, subsequent infusions may be given over 60 minutes. If the second infusion is also well-tolerated, all following infusions might be administered over 30 minutes.
Dosage:
The dosage of Avastin varies depending on the type of cancer being treated, the general health of the patient, and how well the patient handles the treatment. Your healthcare provider will determine your specific dose and schedule.
Frequency of Administration:
Avastin is typically administered once every two weeks. However, the frequency can vary based on the cancer type and stage, and the treatment regimen it is part of.
Active Ingredient: Bevacizumab
Avastin is not suitable for everyone. Patients with the following conditions should discuss their health with their healthcare provider before starting Avastin:
Hypersensitivity to bevacizumab or any component of the product.
Pregnancy: Avastin can cause harm to the unborn baby when administered to a pregnant woman.
Recent surgery or plans to undergo surgery: Avastin can interfere with wound healing.
Patients should be monitored for severe side effects, and treatment should be discontinued if serious reactions occur.
Avastin can potentially interact with other medications, which can alter how Avastin or the other medications work. It is crucial to inform your healthcare provider of all medications you are taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements.
Noteworthy interactions include:
Common Side Effects:
How long do Avastin side effects last?
Most mild side effects of Avastin tend to improve in a few days or a couple of weeks. If side effects last longer or are troublesome, it’s recommended to talk with your doctor.
How long does Avastin eye injection stay in your system?
Avastin can stay in your system for about 4 months after you stop using it.
What happens when you stop taking Avastin?
Avastin can stay in your system for about 4 months after you stop using it, but its levels decrease steadily over that time. The duration in your system doesn’t always affect how long side effects may last.
Does Avastin cause hair loss?
Hair loss is reported as a side effect of Avastin, but it’s not common.
How long can you take Avastin for brain cancer?
The duration of Avastin treatment for brain cancer varies based on the individual’s response to the treatment. It’s usually given once every 2 to 3 weeks and continues for as long as it controls the cancer.
Is Avastin chemotherapy or immunotherapy?
No, Avastin is not a chemotherapy or immunotherapy drug. It’s a type of drug known as a monoclonal antibody, which is a type of targeted therapy.
How does Avastin work?
Avastin works by blocking a protein called vascular endothelial growth factor, or VEGF. This prevents the growth of new blood vessels, including those that feed tumors, which can slow the growth and spread of tumors.
What are the most common side effects of Avastin?
The most commonly reported side effects of Avastin include bleeding (such as nosebleeds), headache, high blood pressure, dry skin, and runny or stuffy nose.
Is Avastin a last resort for glioblastoma?
Avastin is used in the treatment of recurrent glioblastoma, but it’s not necessarily considered a “last resort”. It may extend survival time, but it’s not a cure.
