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Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Akeega is a medication specifically formulated for the treatment of advanced prostate cancer. This dual-action therapy combines two powerful active ingredients, Abiraterone and Niraparib, which work synergistically to target and inhibit cancer cell growth. Abiraterone decreases the production of certain hormones that can promote cancer growth, while Niraparib is a PARP inhibitor that helps prevent cancer cells from repairing their damaged DNA, leading to their death.
Akeega is designed for patients who have not responded adequately to other cancer therapies. Its innovative approach offers a new hope for extending life and improving the quality of life in patients dealing with advanced stages of prostate cancer. Before you buy Akeega, it is crucial that you talk to your healthcare provider about potential side effects and insulin Akeega cost.
| Fact Table | |
|---|---|
| Formula | Abiraterone C24H31NO and Niraparib C11H12N4O |
| License | FDA approved |
| Bioavailability | Abiraterone: Approx. 10%, Niraparib: Approx. 73% |
| Legal status | Prescription drugs |
| Chemical Name | Abiraterone acetate & Niraparib tosylate monohydrate |
| Elimination half-life | Abiraterone: ~12 hours, Niraparib: ~36 hours |
| Dosage (Strength) | Abiraterone 500 mg / Niraparib 200 mg |
| Pregnancy | Contraindicated; not to be used during pregnancy |
| Brands | Akeega |
| Protein binding | Abiraterone: ~99%, Niraparib: ~83% |
| PubChem CID | Abiraterone: 132971, Niraparib: 24958200 |
| MedlinePlus | Not listed specifically for Akeega |
| ChEBI | Abiraterone: 63483, Niraparib: 132072 |
| ATC code | Abiraterone: L02BX03, Niraparib: L01XX54 |
| DrugBank | Abiraterone: DB05812, Niraparib: DB11722 |
| KEGG | Abiraterone: D09706, Niraparib: D09727 |
| Routes of administration | Oral |
Akeega prostate cancer treatment is administered orally in the form of tablets. It is crucial to follow the prescription guidelines provided by your healthcare provider to ensure optimal effectiveness and safety. Typically, the prescribed dose is one tablet per day.
Active Ingredients: Abiraterone acetate and Niraparib.
Patients with severe liver or kidney impairment should use Akeega with caution.
Inform your doctor about any history of allergic reactions to the active or inactive components of Akeega.
Akeega is not recommended for use during pregnancy or while breastfeeding.
The safety and efficacy of Akeega in pediatric patients have not been established.
Akeega can interact with a variety of medications and substances, which can affect how it works or increase the risk of serious side effects:
CYP3A4 Inducers (e.g., rifampicin, phenytoin): These drugs can reduce the effectiveness of Akeega by increasing the metabolism of its active ingredients.
CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir): These drugs can increase the levels of Akeega's active ingredients, potentially leading to toxicity.
Food Interactions: High-fat meals can increase the absorption of Abiraterone, potentially leading to higher blood levels and increased side effects.
Always inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking before starting treatment with Akeega.
While Akeega is effective in treating prostate cancer, it may cause side effects in some patients. Common side effects include:
What is Akeega?
Akeega is a prescription medicine used to treat certain types of prostate cancer. It is used together with prednisone and is the first dual-action tablet combining a PARP inhibitor with abiraterone acetate.
Is Akeega FDA approved?
Yes, Akeega received FDA approval on August 11, 2023.
What is the indication of Akeega?
Akeega is indicated for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) that has an abnormal BRCA gene (BRCA-positive). This refers to prostate cancer that has spread to other parts of the body and no longer responds to medical or surgical treatment that lowers testosterone.
What is the mechanism of action of Akeega?
Akeega works by slowing prostate cancer cells’ ability to grow and by causing prostate cancer cells to die. It contains two active ingredients: niraparib, a highly selective poly (ADP-ribose) polymerase (PARP) inhibitor, and abiraterone acetate, an androgen biosynthesis inhibitor.
What does Akeega treat?
Akeega is used to treat metastatic castration-resistant prostate cancer (mCRPC) that has an abnormal BRCA gene (BRCA-positive).
What are the active ingredients in Akeega?
The active ingredients in Akeega are niraparib and abiraterone acetate.
What size are Akeega tablets?
Akeega 100 mg/500 mg film-coated tablets are orange, oval, and measure 22 mm x 11 mm.
