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Only Available By Prescription
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A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug.
Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount.
Emend (aprepitant) belongs to a class of medications known as substance P/neurokinin 1 (NK1) receptor antagonists. It works by blocking the actions of chemicals in the body that trigger nausea and vomiting. By doing so, Emend effectively prevents these distressing side effects, which can occur both in the immediate aftermath of chemotherapy and in the days that follow.
This medication is not a one-size-fits-all solution but a targeted approach to manage CINV, making it a crucial part of comprehensive cancer care. Its efficacy in preventing nausea and vomiting can help patients maintain their nutrition, hydration, and overall well-being, thereby supporting their recovery and continuity of cancer treatment.
Before you buy Emend, you must talk to your healthcare provider about potential side effects and Emend cost.
| Fact Table | |
|---|---|
| Formula | C23H21F7N4O3 |
| License | FDA approved |
| Bioavailability | 60–65% |
| Legal status | Prescription Drugs |
| Chemical Name | Aprepitant |
| Elimination half-life | 9–13 hours |
| Dosage (Strength) | 80mg, 1x125mg+2x80mg, 125mg |
| Pregnancy | Consult Doctor |
| Brands | Emend |
| Protein binding | less than 95% |
| PubChem CID | 6918365 |
| MedlinePlus | a604003 |
| ChEBI | 499361 |
| ATC code | A04AD12 |
| DrugBank | DB00673 |
| KEGG | D02968 |
| Routes of administration | By mouth |
Emend is available in capsule form and as an injectable solution to be administered under the guidance of a healthcare professional. The dosing regimen typically involves taking Emend before the start of chemotherapy. Depending on the specific chemotherapy protocol and the individual's response to treatment, it may continue for a few days afterward.
Before Chemotherapy
The initial dose of Emend is usually taken 1 hour before the start of chemotherapy. This preemptive step ensures the medication has adequate time to exert its effects, setting a protective barrier against CINV.
After Chemotherapy
Subsequent doses are generally recommended for the following two days after chemotherapy. This continued administration helps maintain the medication's effectiveness, providing sustained relief from nausea and vomiting.
It is essential to follow the dosing instructions your healthcare professional provides closely. They will tailor the regimen based on your specific chemotherapy schedule and your body's response to treatment.
The active ingredient in Emend is aprepitant.
Before starting Emend, it is crucial to discuss your complete medical history with your healthcare provider. This includes any allergies, pre-existing conditions, and other medications you're taking. Emend may not be suitable for everyone, and certain situations may require dose adjustments or extra monitoring.
Certain medical conditions can interact with Emend's mechanism of action. For instance, patients with liver issues may need dose adjustments or additional monitoring during treatment with Emend.
Emend's safety during pregnancy or breastfeeding is not fully established. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits with your healthcare provider.
Emend can interact with a wide range of medications, potentially affecting their efficacy or increasing the risk of side effects. It's essential to inform your healthcare provider if you are taking blood thinners, oral contraceptives, and certain medications for seizures, depression, or fungal infections. This list is not exhaustive, and individuals' interaction potential can vary. Your healthcare provider will review your current medications to ensure that Emend can be safely integrated into your treatment plan.
While Emend medication is effective in preventing CINV, it can cause side effects in some individuals. The most common side effects include:
These side effects are generally mild and temporary. However, if you experience any severe or persistent side effects, it's important to contact your healthcare provider immediately.
What is Emend (Aprepitant)?
Emend is a drug that belongs to a class of medications called antiemetics. It is used to prevent nausea and vomiting caused by chemotherapy.
What conditions is Emend approved for?
Emend is FDA-approved for use with other antiemetic agents to prevent acute or delayed nausea and vomiting caused by chemotherapy.
How does Emend work?
Emend produces its anti-nausea effects by binding to a specific receptor in brain cells called P/neurokinin 1 (NK1). This binding blocks a pathway that normally triggers nausea or vomiting.
How is Emend administered?
It is administered orally, and the dose depends on several factors, including the condition being treated, the particular regimen being used, and the patient's overall health.
What is the typical regimen of Emend?
Emend is taken for three days, typically an hour before and for the two days following chemotherapy.
How are patients typically monitored?
Patients usually have scheduled meetings with their healthcare provider while being treated with Emend.
What are the side effects of Emend?
Side effects of treatment with Emend are uncommon and include fatigue, weakness, hiccups, dizziness, diarrhea, constipation, loss of appetite, abdominal discomfort, heartburn, and changes in liver or kidney function laboratory tests.
What should I do if I miss a dose?
Contact your healthcare provider or pharmacist for instructions if you miss a dose.
What may interact with Emend?
Emend has drug interactions with several agents, so patients who are receiving agents that interact with Emend may be closely monitored.
Can Emend be used for other purposes?
Physicians can prescribe medication for conditions other than those for which the FDA has approved the drug.
