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Ranexa, an antianginal medicine, is used to treat chronic chest pain that has not responded to other medications. Ranexa works by improving blood flow to help the heart work more efficiently. Ranexa is used in combination with other medicines.

You should not take Ranexa if you have liver disease, hypokalemia (low levels of potassium in your blood), or a personal or family history of Long QT syndrome, which is when the heart is not beating correctly. Ranexa should not be taken together with certain medicines to treat heart rhythm disorders, malaria, infections, mental illness, pain, cancer, or stomach disorders. Before you take ranolazine, tell your doctor about all other medications you are using. Ranexa is not for use during an acute (emergency) attack of angina. Continue using any other medicines prescribed by your doctor (such as nitroglycerin) to treat acute angina.